iPS Factor is a next-generation reverse aging factor developed by applying proprietary iPS cell research technology. Flora Clinic Ikebukuro, specializing in cosmetic surgery and dermatology, offers treatments utilizing both the iPS Cell Private Bank and iPS Factor as new options for anti-aging therapy for the entire body and face, as well as AGA and thinning hair treatment.
We provide advanced medical care that comprehensively supports the condition of your skin, scalp, and entire body, focusing not only on your current beauty but also on your “future health and youth.”
At Flora Clinic Ikebukuro, a cosmetic surgery and dermatology clinic, we value evolving anti-aging medicine beyond “treatments to enhance current appearance” into “medicine that protects future health and youth.” Our initiatives symbolizing this philosophy are iPS Factor, utilizing iPS cells, and the iPS Private Bank.
iPS cells represent a groundbreaking technology for cellular rejuvenation, established by Professor Shinya Yamanaka of Kyoto University and his team. The iPS Private Bank enables the creation and cultivation of iPS cells from your own blood, followed by long-term banking (storage) in an ultra-low temperature environment. I consider this not merely a medical service, but an extremely valuable medical asset: “the lifelong possession of your own cells in the very young state of a 4-day-old fertilized egg.”
iPS cells hold the potential to proliferate as needed and be utilized for various applications. One such application is iPS Factor, developed by applying insights from iPS cell research. iPS Factor is a next-generation anti-aging and reverse-aging approach that utilizes components derived from iPS cells, aiming to support the condition of skin, scalp, and the entire body at the cellular level.
A major distinguishing feature, unprecedented in conventional aesthetic medicine, is the ability to utilize iPS Factor at the necessary moment, based on iPS cells cultured and stored in the iPS Private Bank.
At our clinic, we position iPS Factor not only as a “treatment for immediate results” but also as medical care for future self-preparation. Aging progresses not only with age but also due to changes in the cellular environment. This is precisely why protecting cells while healthy and establishing a system to utilize them when needed holds great significance.
At Flora Clinic Ikebukuro, a cosmetic surgery and dermatology clinic, we do not uniformly recommend the iPS Private Bank or iPS Factor to everyone. We carefully listen to each patient’s life stage, health status, and values, assess suitability from a medical perspective, and then make our proposal.
Considering “present beauty” and “future health” simultaneously—that is the anti-aging medicine we aim for in the iPS cell era.
1. Who We Recommend iPS Banking & iPS Factor For
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Those who wish to store their own cells for future use
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Those who want to prepare for future medical needs beyond current beauty and anti-aging care
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Those who trust Japan’s iPS cell technology and prioritize safety and management systems
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Those concerned about age-related changes in skin texture and loss of firmness and radiance
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Those concerned about thinning hair/AGA or changes in scalp environment
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Those seeking early care for joint conditions like knee issues
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Those interested in approaches that regulate the cellular environment, not just “shape-building treatments” like hyaluronic acid or thread lifts
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Those who wish to prepare as a medical asset, anticipating future advancements in regenerative medicine and advanced medical treatments
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s from China seeking long-term value in medical care during short stays in Japan
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Those who prioritize thorough explanations from physicians and customized treatment plans
2. What is “iPS Factor,” born from iPS cell research?
1）Background of iPS cell research by Professor Shinya Yamanaka of Kyoto University
iPS cells (induced pluripotent stem cells) are a cellular technology first successfully created in 2006 by Professor Shinya Yamanaka and his team at Kyoto University.
The groundbreaking aspect is that introducing specific factors into somatic cells like skin or blood can revert them to an undifferentiated state similar to fertilized eggs. This achievement earned the Nobel Prize in Physiology or Medicine in 2012.
iPS cells hold the potential to differentiate into cells of any tissue type, driving rapid research progress, particularly in regenerative medicine and drug discovery. Clinical studies for conditions like retinal diseases, heart diseases, and neurological disorders are now underway, garnering global attention as a regenerative medicine technology originating from Japan.
This accumulation of fundamental research has given rise to new medical concepts: “cellular youth” and “reconstruction of the cellular environment.”
2）The concept of “cell-derived factors” utilizing iPS cell technology
iPS Factor is not a treatment involving the transplantation of iPS cells themselves into the body, but rather an approach utilizing “cell-derived components” developed by applying insights from iPS cell research.
It is based on the concept of supporting the cellular environment by focusing on growth factors and intercellular signals identified during the iPS cell culture process.
Unlike conventional stem cell-derived preparations and PRP therapy, which primarily relied on limited growth factors, iPS Factor is characterized by its more multifaceted component composition.
This suggests the potential to comprehensively regulate the overall condition of cells, not just locally in areas like the skin or scalp.
This concept of “preparing an environment conducive to cellular function” rather than “replacing cells” is a major feature of iPS Factor.
Our clinic uses iPS Factor produced from high-quality, medical-grade iPS cells safely cultured and stored by iPS Cell, Inc. and Cell Lab Inc., companies founded by former members of Professor Yamanaka’s laboratory.
3）Advances in Regenerative Medicine Research and Potential Applications in Aesthetic Medicine
In the field of regenerative medicine, perspectives beyond mere “treatment”—such as “prevention” and “preparation for aging”—have gained increasing importance in recent years.
Since aging progresses not due to age itself but through the accumulation of declining cell function and changes in the cellular environment, approaches at the cellular level are considered highly compatible with aesthetic medicine.
Within this trend in regenerative medicine research, iPS Factor represents a new option with anticipated applications in cosmetic medicine and anti-aging treatments.
It is gaining attention not only for purposes like skin care and scalp environment improvement, but also as a comprehensive anti-aging concept focused on future health maintenance.
At Flora Clinic Ikebukuro, a cosmetic surgery and dermatology clinic, we position iPS Factor not as a “temporary rejuvenation treatment” but as a reverse aging therapy that transcends conventional anti-aging medicine, grounded in regenerative medicine research.
3. Features of iPS Factor
1）Compliance with International Standards (US PCPC Ingredient Registration)
As a component produced using “regenerative medicine” technology, iPS Factor is the world’s first to be registered as an ingredient with the U.S. PCPC (Personal Care Products Council), an international standard.
The production technology is patented, and the use of a unique special extraction and concentration method is also a crucial factor from the perspective of quality control and reliability.
Based on these safety considerations and compliance with international standards, our clinic provides medical care that instills confidence in our patients.
2）Contains multiple growth factors and proprietary factors
iPS Factor (iPSF) is a next-generation cell-derived factor developed by applying insights from iPS cell research.
D uring the culture process, iPS cells have been confirmed to secrete multiple growth factors (cytokines) such as FGF, EGF, VEGF, PDGF, and IGF, along with a unique group of factors rarely seen in conventional stem cell supernatant or PRP (platelet-rich plasma) therapy.
PRP therapy primarily utilizes platelet-derived growth factors for wound healing and tissue repair. Stem cell supernatant, on the other hand, uses components extracted from specific stem cell culture media to target localized cell activation.
In contrast, iPS Factor is based on the concept of comprehensively supporting the entire cellular environment, focusing on the diverse component composition observed during iPS cell culture.
The novel components contained in iPS Factor promote whole-body activation and stress resistance, enhancing effects such as beautiful skin, hair growth, and regeneration.
Research data suggests a higher increase in hyaluronic acid and collagen production compared to conventional stem cell-derived products and PRP therapy. A key characteristic of iPS Factor is its independence from reliance on a single growth factor.
At Flora Clinic Ikebukuro, a cosmetic surgery and dermatology clinic, we prioritize selecting and combining treatments based on the patient’s goals and condition, rather than simply comparing these treatments in terms of superiority.
3）Safety considerations based on autologous technology and compliance with international standards
iPS Factor is based on technology developed with a strong emphasis on the concept of autologous cells, grounded in iPS cell research.
Because this approach focuses on the information inherent in the patient’s own cells, it is considered to have high compatibility with the body, offering safety considerations compared to conventional exogenous components.
Furthermore, a key feature of iPS Factor is that it utilizes “cell-derived components” rather than transplanting the cells themselves into the body.
This enables practical and cautious application as aesthetic and anti-aging medicine while incorporating the principles of regenerative medicine.
4. The Relationship Between the iPS Private Bank and iPS Factor
“Anti-Aging You Can Use Now” and “Medical Assets for the Future”
The iPS Private Bank is a service that creates and cultivates iPS cells from your own blood and stores them long-term in an ultra-low temperature environment (banking).
This is not merely cell storage; it is based on a new medical concept: “preserving your own young cells in a state ready for use when needed.”
While iPS cells can be created from cells of any age, the quality of cells gradually changes with aging and disease . Therefore, culturing and banking cells while they are relatively healthy early on holds significant meaning.
The iPS Private Bank is considered a lifelong medical asset, serving as a forward-thinking “cell reserve” for the future.
iPS Factor is an approach developed by applying insights from iPS cell research and culture technology, now applicable in contemporary anti-aging medicine.
Rather than transplanting iPS cells directly, it aims to support the condition of the skin, scalp, and entire body from the cellular environment by utilizing components derived from iPS cells.
In the future, it is envisioned that iPS cells cultured and stored in an iPS private bank could serve as a foundation, enabling their utilization as iPS Factor as needed.
This represents a significant feature not seen in conventional aesthetic medicine, bridging “treatments available now” with “future medicine.”
At Flora Clinic Ikebukuro, we position the iPS Private Bank and iPS Factor not as one-off treatments or trendy procedures, but as part of a comprehensive anti-aging and health strategy considering the entire lifespan.
We provide thorough explanations and careful suitability assessments to ensure these options are available not only for current skin or hair thinning concerns but also for those considering future health and quality of life (QOL).
The “preparation” offered by the iPS Private Bank and the “current care” provided by iPS Factor.
By combining these two approaches, we believe anti-aging medicine will evolve from “temporary rejuvenation” to “medicine that protects your future.”
5. iPS Factor Treatment Methods and Target Areas
iPS Factor is an anti-aging treatment utilizing cell-derived components developed from insights gained through iPS cell research. The administration method is selected based on the treatment goal and target area.
At Flora Clinic Ikebukuro, a cosmetic surgery and dermatology clinic, we propose the appropriate method and treatment area after a consultation and examination by a physician.
1）Facial Aesthetics (Skin Rejuvenation & Anti-Aging Care)
For facial aesthetics, iPS Factor is injected locally according to skin condition and concerns, aiming to improve the skin environment at the cellular level.
This approach provides multifaceted support for the cellular environment, addressing complex concerns associated with aging such as loss of firmness and radiance, dryness, nasolabial folds, sagging, fine lines, and age-related changes in skin texture.
U nlike traditional treatments like hyaluronic acid or Botox that focus on shaping, this treatment is positioned to improve the skin’s own condition. It can also be combined with other cosmetic treatments.
2）Hair Loss/AGA (Scalp & Hair Care)
For thinning hair and AGA treatment, iPS Factor is directly injected into the scalp areas of concern to improve the environment around the hair follicles.
Hair papilla cells and the scalp environment are susceptible to aging, reduced blood flow, inflammation, and other factors, making a cellular-level approach crucial.
iPS Factor is not a treatment that “forces” hair growth; rather, it supports creating an environment conducive to hair growth. It is sometimes used in combination with oral medications, topical treatments, or other injection therapies.
3）Knee (Joint Care for Conditions like Osteoarthritis)
iPS Factor is utilized not only in the field of aesthetics but also for joint care, such as osteoarthritis of the knee.
Through local injection around the knee joint, it aims to optimize the environment within the joint and surrounding tissues, providing support against condition deterioration due to aging and stress.
It is positioned as an approach that acts on the tissue environment itself, offering a different perspective from conventional injection treatments (such as hyaluronic acid injections).
Suitability varies depending on symptoms and progression, making a physician’s examination crucial.
4）Systemic (Anti-Aging Care via IV Drip)
iPS Factor is also administered systemically via IV drip to comprehensively support overall physical condition.
It addresses not only localized treatment but also fatigue, age-related physical changes, and overall anti-aging care from a cellular environment perspective.
Positioned not only for cosmetic purposes but as “anti-aging medicine with a long-term perspective,” it is sometimes considered as part of regular care.
6. Features of iPS Factor Treatment at Flora Clinic Ikebukuro (Cosmetic Surgery & Dermatology)
At our clinic, we do not offer iPS Factor as a standalone treatment. Instead, we combine it with other cosmetic procedures and anti-aging therapies to design a treatment plan optimized for each patient’s specific goals and condition.
Under our comprehensive medical care system, we prioritize appropriate suitability assessments and safety assurance in providing treatment.
1）Emphasis on Physician Suitability Assessment and Counseling
iPS Factor treatment eligibility is determined by our physicians after a comprehensive examination of the patient’s skin condition, age, overall health, and previous treatment history.
The initial consultation is free of charge. We carefully listen to your concerns and desires, providing scientifically grounded explanations and presenting the risks and benefits.
We take ample time during counseling to address any questions or concerns about treatment, ensuring patients proceed with confidence.
We design an optimal plan that balances “treatment needed now” with “preparation for the future,” taking into account each patient’s individual life circumstances and plans.
2）Combination with Other Treatments
At our clinic, combining iPS Factor with other cosmetic procedures and anti-aging treatments enables treatment designs that pursue more effective and comprehensive beauty enhancement and health maintenance.
Representative examples of such combinations include:
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Combination with Thread Lifts
Combining it with thread lifts, which target facial sagging, allows for simultaneous lifting effects and improvement of the cellular environment.
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Combination with hyaluronic acid injections
Simultaneously performing volume correction with hyaluronic acid and skin quality improvement with iPS Factor enables an approach that enhances both dimensionality and texture.
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Combination with HIFU
Combining HIFU’s tightening effect on fascia and subcutaneous tissue with iPS Factor’s cellular environment support enables an approach that achieves both lifting and maintaining youthfulness.
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Combination with NMN IV Therapy or Stem Cell Culture Medium Injections
Combining with NMN IV drips, which target systemic anti-aging, allows simultaneous pursuit of maintaining youthfulness from within the body and localized skin/tissue improvement.
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Combination with PDF-FD (Plasma Derived Factors-Freeze Dry) Therapy
PDF-FD therapy is a regenerative medical injection treatment using freeze-dried components extracted and concentrated from growth factors found in the patient’s own blood plasma. When injected locally into areas like the skin or scalp, these extracted and concentrated growth factors support cellular repair and regeneration, offering benefits such as improved skin quality and hair thinning.Being derived from the patient’s own blood, it carries a low risk of allergic or rejection reactions. Compared to conventional PRP therapy, it has been reported to have higher growth factor concentration and activity, offering superior continuity and stability of effect.
7. Treatment Process
1）Physician Consultation and Explanation
The physician carefully reviews your current concerns (skin, thinning hair, joints, overall health, etc.), medical history, treatment history, and lifestyle habits.
We will clearly explain the mechanism of iPS Factor and the iPS Private Bank, their expected roles, differences from other treatments (thread lifts, hyaluronic acid, HIFU, PRP, stem cell culture medium, PDF-FD, etc.), and considerations for combining treatments, all from a medical perspective.
For international patients, online counseling via the metaverse is also available.
2）Eligibility Confirmation & Treatment Plan Design
Based on the examination results, the physician will determine suitability for iPS Factor therapy and the iPS Private Bank.
We comprehensively consider the treatment area (face, scalp, knees, whole body), administration method (local injection or IV drip), combination therapies, and treatment intervals to design a customized treatment plan tailored to each individual patient.
3）Consent and Contract
After thoroughly explaining the treatment details, precautions, potential risks, costs, and conditions regarding iPS cell production and storage, we proceed with signing the consent form and contract procedures only when the patient fully understands and agrees.
We do not engage in aggressive sales tactics; treatment proceeds only after the patient has had sufficient time to consider the information.
4）Blood Collection
If using the iPS Private Bank, blood will be drawn for iPS cell production.
The collected blood will be sent to a specialized facility under strict management protocols and proceed to the iPS cell production process.
5）iPS Cell Cultivation
iPS cells are created from the collected blood and cultured at a specialized facility.
The generated iPS cells are stored long-term (banked) in an ultra-low temperature environment for future treatment and utilization.
6）Completion of iPS Factor
Approximately six months after iPS cell culture, the iPS Factor, derived from cellular components, is completed.
This iPS Factor is provided in a form usable at our clinic for aesthetic medicine and anti-aging treatments.
7）Confirmation of Treatment Intent
After the iPS Factor is completed, patients consult with their physician to determine when and where to use it, based on their preferences and life stage.
Flexible choices are possible, such as “undergo treatment immediately” or “prioritize storage for future use.”
8）Treatment (iPS Factor Administration)
Based on the treatment plan, the iPS Factor is administered to the target area.
Local injections are used for areas like the face, scalp, and knees, while intravenous infusion is used for whole-body care.
Treatment can be performed on any one or a combination of these four areas.
Combination with other cosmetic procedures is also possible.
9）Subsequent Administration and Follow-up
After treatment, we monitor progress and adjust future administration schedules or treatment plans as needed.
Our clinic provides ongoing support for iPS Factor not as a one-time treatment, but as long-term anti-aging medical care .
8. Risks and Precautions of iPS Factor
iPS Factor treatment is a medical procedure performed under a physician’s examination and suitability assessment.
To prioritize safety, please fully understand the following points.
1）Side Effects
Since iPS Factor therapy uses components derived from your own cells rather than transplanting cells directly into the body, serious side effects have generally not been reported.
However, depending on the treatment method and individual constitution, temporary reactions such as the following may occur:
- Redness, swelling, mild pain, or bruising at the injection site
- Temporary fatigue, flushing, or mild headache after intravenous administration
- In rare cases, you may experience discomfort or mild changes in your physical condition.
These symptoms often improve naturally within a few days, but if you feel something is wrong, please consult a doctor promptly at .
2）Precautions for Treatment
iPS Factor therapy will be administered with the following points in mind.
- Treatment effects and responses vary from person to person.
- Treatment content may be adjusted or postponed depending on medical history, physical condition, or medication status
- Combination with other aesthetic or regenerative treatments (thread lifts, hyaluronic acid, HIFU, PRP, stem cell culture medium, PDF-FD, etc.) will be planned and administered under the physician’s judgment.
- After treatment, please follow the physician’s instructions and undergo follow-up observations
At Flora Clinic Ikebukuro, a cosmetic surgery and dermatology clinic, we prioritize thorough pre-treatment explanation and informed consent.
3）Cases where treatment cannot be performed or requires careful consideration
From a safety perspective, iPS Factor treatment may not be available or may require careful consideration in the following cases:
- During treatment for malignant tumors (cancer) or if cancer is active
- If you have infectious diseases such as HIV infection, hepatitis B, or hepatitis C
- Severe underlying medical conditions or immune system disorders
9．Fees
1) iPS Cell Production and Storage Fees
| Item | Fee |
|---|---|
| iPS Cell Production Fee (Culture Only) | Consultation required |
| iPS Cell Production Fee (Culture) | Consultation required |
*When applying simultaneously with iPS Factor, select from the following plans:
2)iPS Factor Fee Plan
| Plan | Details | Fee |
|---|---|---|
| Standard | iPS Factor Single Treatment | Consultation required |
| Silver | iPS Factor 1 Treatment + 3 Additional Treatments | Consultation required |
| Gold | iPS Factor 2 treatments OR 1 Treatment + 6 Additional Treatments | Consultation required |
*Treatment details and number of sessions will be determined based on the physician’s examination.
3)Total Plan (iPS Cell Creation + iPS Factor)
| Plan | Total Fee |
|---|---|
| Standard | Consultation required |
| Silver | Consultation required |
| Gold | Consultation required |
*Treatment details and number of sessions will be determined based on the physician’s examination.
Annual Fee (iPS Private Bank Club)
| Item | Fee |
|---|---|
| Annual Fee | Consultation required |
- iPS cell storage and management
- iPS cell provision
- Regular inspections
- Guarantee service
- Regenerative Medicine Consultation Desk
*Annual fee details may vary depending on contract terms.
10. Frequently Asked Questions for Visitors from China
Q1. Can I receive counseling even if I don’t speak Japanese? Also, is it possible to have a preliminary consultation while still in China?
Yes, it is possible.
Even if you don’t speak Japanese, we can clearly explain the treatment details and potential risks using translation tools and Chinese-language materials.
Additionally, online counseling using the metaverse is available while you are still in China.
Consulting with a doctor before your trip to Japan allows you to confirm the treatment details and injection site direction, ensuring a smooth procedure upon arrival.
Even if you are on a short stay or receiving aesthetic medical treatment in Japan for the first time, you can consult with us with peace of mind.
Q2．Are iPS cells and iPS factors safe?
iPS cells are a technology established by Professor Shinya Yamanaka of Kyoto University and others, and research and clinical applications are advancing both in Japan and overseas.
The iPS Private Bank employs manufacturing techniques that reduce the risk of tumorigenicity and has established a system to confirm the absence of abnormalities in causative genes prior to use.
iPS Factor is not a treatment involving the transplantation of the cells themselves, but rather a method using cell-derived components. It is carefully administered as cosmetic medicine and elective treatment.
Q3．How long can iPS cells be stored?
iPS cells are cryopreserved at ultra-low temperatures below −150°C and can be stored long-term as long as the contract remains active.
Cryopreserved cells can be thawed and cultured as needed and are positioned as a “medical asset” that can theoretically be used throughout one’s lifetime.
Q4．Can stored iPS cells be used multiple times?
Compared to other stem cells, iPS cells are characterized by their high proliferative capacity.
By expanding a single batch of iPS cells, their use for multiple treatments or research applications is envisioned.
Q5．Can stored iPS cells be used for family members?
In principle, iPS cells created and stored in an iPS private bank are for the exclusive use of the individual.
Even among relatives, there is a possibility of immunological incompatibility, posing a risk of immune rejection. Therefore, use by third parties is not anticipated.
Q6．When is the best time to start using iPS Private Bank?
While iPS cells can be created at any age, there is significant value in preserving cells from a relatively healthy state early on.
More people are choosing this option based on the idea of “preparing while healthy” in anticipation of future treatments and anti-aging medicine.
Q7．Can I receive iPS Factor therapy without using an iPS Private Bank?
No, it is not possible.
iPS Factor Therapy is fundamentally based on the premise of using an iPS Private Bank.
However, the idea is that cultivating and storing iPS cells with an eye toward the future expands the range of possibilities for their use when needed.
Q8．Is treatment possible even with a short stay in Japan?
Yes, it is possible.
We adjust counseling, blood sampling, and treatment schedules to accommodate your visit schedule.
Q9．Is Chinese language support or interpretation available?
To ensure Chinese inbound patients can receive treatment with peace of mind, we provide Chinese-language materials and explanations using translation tools.
Please inquire in advance for details on specific support options.
Q10．Is it a completely appointment-based system?
Yes. Both the iPS Private Bank and iPS Factor therapy are offered by appointment only and with limited availability.
We request advance appointments to ensure sufficient time for consultation and explanation.
Summary｜The Choice for Japan-Origin iPS Anti-Aging Medicine, Looking Toward the Future
The iPS Factor Therapy and iPS Private Bank offered by Flora Clinic Ikebukuro, a cosmetic surgery and dermatology clinic, represent next-generation anti-aging and reverse-aging medicine based on Japan’s pioneering iPS cell research.
Beyond addressing beauty, hair loss, and joint care, a major feature is the ability to preserve your own cells for future use, utilizing them when needed.
Our clinic prioritizes thorough consultations by physicians and appropriate suitability assessments. We also accommodate preliminary consultations while you are in China and short-term stays.
For those considering both “present beauty” and “future health,” Flora Clinic Ikebukuro’s iPS anti-aging & reverse aging medicine offers a reliable and valuable choice.